By Gordon Campbell
This concise sensible consultant introduces the research, prognosis, and therapy of universal metabolic bone illnesses and issues of calcium metabolism. the entire commonest such illnesses are coated, together with osteoporosis, osteomalacia, malignant bone sickness, Paget's affliction, and hyper- and hypocalcaemia. the quantity concludes with a short examine many of the rarer stipulations that would be encountered. The publication summarizes in short the latest advances within the realizing of the etiology of those ailments and offers beneficial counsel on therapy regimes. This quantity could be a useful advisor for the numerous common physicians, rheumatologists, geriatrics experts, and endocrinologists who stumble upon sufferers with bone issues.
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Additional resources for The Management of Common Metabolic Bone Disorders
1991). Osteoporosis: current techniques and recent developments in quantitive bone densitometry. Radiology Clinics of North America 29, 49-76. M. (1984). The cellular basis of bone remodelling. The quantum 28 Pathogenesis/investigation of metabolic bone disease concept re-examined in the light of recent advances in cell biology of bone. Calcified Tissue Internal. 36, S37^5. , ed. (1983). Bone Histomorphometry. Techniques and Interpretations. CRC Press Inc, Boca Raton. G. (1990). Bone cell biology: the role of cytokines and other mediators.
Clinical features include pain and swelling of an extremity, usually unilateral and often associated with signs of autonomic instability. Radiological investigation shows patchy or diffuse demineralisation, particularly in the subchondral region. Later there may be some atrophy of the subcutaneous tissue, muscle wasting and radiological evidence of more severe osteopenia in the affected region. In some cases, complete resolution occurs whilst, in others, there are permanent sequelae; occasionally the disease shows a migratory pattern.
2 Osteoporosis Definition, prevalence and epidemiology Definition Osteoporosis is characterised by reduced bone mass and by increased risk of fragility fracture. The term osteopenia is used to describe a reduction in bone mass whilst osteoporosis generally denotes the presence of fracture. Fragility fractures are defined as fractures occurring after a fall from standing height or less and may occur without any obvious preceding trauma. The three most common fracture sites in osteoporosis are the spine, the femoral neck and the radius, but fractures may also occur at a number of other sites, particularly the pelvis and humerus.