By William H. Daughaday (auth.), Derek LeRoith, Mohan K. Raizada (eds.)
An crucial point within the improvement and practical integrity of all organisms is intercellular communique. this is often completed through the secretion of soluble messenger molecules which for that reason engage with receptor-effector pathways within the responsive cells. Hormones are characteristically outlined as chemical messengers synthesized by means of endocrine glands. not like hormones produced by way of endocrine glands, development components are hormone-related elements produced by means of many tissues and play a tremendous function in controlling progress and improvement. whereas the precise physiological roles of development components have not begun to be elucidated, they play vital roles within the law of mobile proliferation and/or differentiation in the course of ontogenesis, development and differentiation. in the course of contemporary years there was a considerable bring up in examine regarding peptide development components, their receptors, and modes of motion. With the invention and characterization of diverse development components, it grew to become transparent that those progress components had a number of good points in universal with vintage hormones in addition to with oncogenes. additionally, there are unique households of development components dependent both on structural or useful similarities.
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Extra info for Molecular and Cellular Biology of Insulin-like Growth Factors and Their Receptors
G. Rosenfeld, structural and immunohistochemical characterization of insulinlike growth factor I and II receptors in the murine central nervous system, Endocrinology 123:1023 (1988). 8. K. L. Valentino, I. Ocrant, and R. G. Rosenfeld, Developmental expression of insulin-like growth factor II receptor-immunoreactivity in the rat CNS (submitted for publication) . 9. M. Van Houten, B. I. Posner, B. M. Kopriwa, and J. R. Brawer, Insulin binding sites in the rat brain: In vivo localization to the circumventricular organs by quantitative radioautography, Endocrinology 105:666 (1979).
Endocrinol 2:47-54. Casella SJ, Smith EP, Van Wyk JJ, Joseph DR, Hynes MA, Hoyt EC and PK Lund (1987) Isolation of rat testis cDNAs encoding an insulin-like growth factor-I precursor. DNA 6:325-330. Hynes MA, Brooks PJ, Van Wyk JJ, and ~K Lund (1988) Insulin-like growth factor II messenger ribonucleic acids are synthesized in the choroid plexus of the rat brain. Endocrinol 2:47-54. Mohan S, Jennings JC, Linkhart TA, and DJ Baylink (1988) Primary structure of human skeletal growth factor: homology with human insulinlike growth factor-II.
In a different animal model, Mathews et al 74 created a line of transgenic mice which carry the human IGF-I gene and which overexpress IGF-I peptide. These animals demonstrated selective organomegaly, with the brain growing 50% heavier than in control mice. GH mRNA accumulation was reduced to approximately 40% of control, but circulating GH levels were below the level of detection, indicating that longterm exposure to high levels of IGF-I inhibits GH synthesis and release. The role of the IGFs in the regulation of GH secretion has also been investigated in humans.