Download Intestinal Microbiota in Health and Disease: Modern Concepts by Eduardo J. Schiffrin, Philippe Marteau, Dominique Brassart PDF

By Eduardo J. Schiffrin, Philippe Marteau, Dominique Brassart

Now thought of an organ with shielding and metabolic features, the intestinal microbiota performs a massive function within the neighborhood host immune method improvement and schooling. It contributes to the new release of a homeostatic stability characterised by way of the means to react opposed to pathogens whereas closing hyperresponsive/tolerant opposed to commensals. This homeostatic reaction relies on micro organism and bacterial product sensing by means of innate immune cells and their molecular asset on the intestinal mucosa. This ebook captures the big development that has been comprehensive during this box lately.

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Immunol. 34: 3389–3400. , E. Elinav, T. A. Flavell. 2012. Inflammasomes: far beyond inflammation. Nat. Immunol. 13: 321–324. J. 1997. Intestinal flora and endogenous vitamin synthesis. Eur. J. Cancer. Prev. 6 Suppl. 1: S43-45. , T. Hisatsune, K. Nishijima, H. Kato, O. Shiho and S. Kaminogawa. 1995. CD4+ T cells anergized by high dose feeding establish oral tolerance to antibody responses when transferred in SCID and nude mice. J. Immunol. 154: 6238–6245. S. V. I. Gordon. 2003. Angiogenins: a new class of microbicidal proteins involved in innate immunity.

Iron, Copper, and Manganese in Germfree and Conventional Rats. J. Nutr. 86: 159–168. , M. Urbano, B. Valzasina, M. Francolini, G. Rotta, R. Bonasio, F. P. Kraehenbuhl and P. Ricciardi-Castagnoli. 2001. Dendritic cells express tight junction proteins and penetrate gut epithelial monolayers to sample bacteria. Nat. Immunol. 2: 361–367. , E. Im, M. Riegler, E. Kokkotou, M. O’Brien and C. Pothoulakis. 2005. Pathophysiological role of Toll-like receptor 5 engagement by bacterial flagellin in colonic inflammation.

2007). As the effector cytokines Th17 cells produce IL-17A, IL-17F, IL-21 and IL-22 that further direct the immune responses. Studies showed that Th17 cells are necessary for the protection from Citrobacter rodentium, Klebsiella pneumoniae (Happel et al. 2005) and Salmonella typhimurium (Godinez et al. 2009; Schulz et al. 2008). However, IL-17 producing lymphocytes seem to be involved in IBD pathogenesis, but the exact role of Th17 cells in this process is still to be determined. Tregs cells Active suppression of the immune responses by Treg cells is particularly important in the intestine to prevent the excessive responses to numerous microflora-derived antigens.

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