By Shyam Varadarajulu MD, James W. Freston MD, PhD (auth.), James W. Freston MD, PhD (eds.)
The discovery of H. pylori's significant position in numerous acid-related illnesses has wrought profound adjustments within the scientific method of this relatives of stipulations. In illnesses of the Gastroesophageal Mucosa: The Acid-Related issues, medical specialists synthesize for the training surgeon the entire very important advancements within the prognosis and therapy of those quite common health conditions. those hugely skilled writers specialize in stipulations during which gastric acid is essentially implicated in particular pathophysiologies, and within which the modulation of gastric acidity affects the scientific reaction. They tackle the evaluate of sufferers suspected of harboring either peptic ulcers and ulcers from different motives, with emphasis on novel points of H. pylori an infection. New info is usually supplied to aid clinicians in successfully dealing with sufferers with dyspepsia and within the prognosis and therapy of gastroesophageal reflux ailment (GERD), together with its extraesophageal manifestations and top gastrointestinal bleeding. the medicine used to regard those acid-related illnesses are totally discussed.
Authoritative and hugely readable, illnesses of the Gastroesophageal Mucosa: The Acid-Related problems distills a wealth of state of the art scientific perform into one readable quantity that might support each clinician deal with sufferers with contemporary top in diagnostic and remedy practices.
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Extra resources for Diseases of the Gastroesophageal Mucosa: The Acid-Related Disorders
In a comparative study in 161 patients, there was 95% concordance between the results ofthe 13C-urea blood tests and UBTs (18); the sensitivity and specificity of the urea blood test was 92 and 96%, respectively. In a separate study of 121 patients, with histology as the gold standard for H. pylori infection, the sensitivity and specificity of the 13C-urea blood test was 89% and 96%, respectively (19). The sensitivity of the 13C-urea blood test will also be impaired if the patient is taking any of the medicines that can impair interpretation of the UBT.
Philadelphia: JB Lippincott, pp. 1347-1430. Leoci C, Ierardi E, Chiloiro M, et al. (1995) Incidence and risk factors of duodenal ulcer. J Clin GastroenteroI20:104-109. Hopkins RJ, Girardi LS, Tumey EA. (1996) Relationship between H. pylori eradication and reduced duodenal and gastric ulcer recurrence: a review. Gastroenterology 11 0: 1244-1252. Beardshall K Moss S, Gill J, et al. (1992) Suppression of Helicobacter pylori reduces gastrin releasing peptide stimulated gastrin release in duodenal ulcer patients.
Children infected with H. pylori are more likely to have parents and siblings infected with H. pylori than children who are not infected (15). However, the isolates may not be the same within each family member, implying the involvement of other sources IATROGENIC TRANSMISSION Iatrogenic spread has also been documented. A contaminated pH probe infected 17/34 consecutive patients (16). In another study, a volunteer was infected with a contaminated endoscope. The iatrogenic risk of transmission has been estimated at 411 000 endoscopies in the developed world.