By William O. III. Dobbins
Diagnostic Pathology of the Intestinal Mucosa - An Atlas andReview of Biopsy Interpretation deals a accomplished review of intestinal mucosal constitution as outlined via peroral or endoscopic biopsy specimens acquired in basic and ailment states. It describes small intestinal biopsy pathology along side morphologic, sensible, and pathophysiologic correlations. regimen tools of processing tissues for mild microscopy, electron microscopy, histochemistry, and light-weight- and electron- microscopic-immunoperoxidase recommendations are offered in order that the amateur within the quarter of intestinal constitution could have an simply obtainable reference for developing a morphologic laboratory.
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Extra resources for Diagnostic Pathology of the Intestinal Mucosa: An Atlas and Review of Biopsy Interpretation
Example text
Ls These cells are present throughout the small intestine. 4. S cells produce secretin and are present in the epithelium of the duodenum and jejunum. Their granules are round to moderately irregular in shape, 180 to 220 nm in size, and of high density; a narrow clear space often separates the granule contents from the surrounding membrane. S-cells have some similarities to Dl cells. 5. I cells produce cholecystokinin and are found in the duodenum, jejunum, and occasionally in the ileum. They have round to slightly irregular granules 250 to 300 nm in diameter, with dense cores, and they bear a close resemblance to L cells (Figures 3-23).
IG cells (intestinal gastrin-producing cells) are found in the duodenum, jejunum, and ileum. The granules are round, dense, and 190 ± 30 nm in diameter and resemble the granules seen in Dl cells (Figure 3-21). Most intestinal gastrin seems to originate from these cells, not from the very sparse duodenal G cells. 3. D cells produce somatostatin and are characterized by the presence of round, moderately dense secretory granules measuring 300 to 400 nm in diameter (Figure 3-22). The surrounding membrane is closely applied to the granule matrix and sometimes has a "nibbled at" appearance.
The lateral bridges are composed of a 1l0-kilodalton (kd) protein with four associated calmodulin molecules? The terminal web region is organized in a trilayered fashion, with each layer composed of different arrangements and types of filaments. Each layer correlates with the three levels of the junctional complex (tight, intermediate, and desmosome)6,8 (Figure 3-6). The apical region is adjacent to the tight junction and contains predominant rootlets. The intermediate region consists of two zones, an apical and a basal zone.