Download Cytochrome P450 2D6: Structure, Function, Regulation and by Shufeng Zhou PDF

By Shufeng Zhou

Cytochromes are proteins that catalyze electron move reactions of famous metabolic pathways and are categorized in a number of superfamilies. The CYP, or P450, superfamily debts for ninety% of the oxidative metabolism of scientific medications. One member of this superfamily, P450 2D6 (or CYP2D6), singlehandedly metabolizes approximately 25% of all medicines within the human liver. Cytochrome P450 2D6: constitution, functionality, rules, and Polymorphism experiences the present wisdom of CYP2D6 in addition to the maturing physique of proof indicating its value to scientific and pharmacological researchers and practitioners.

This booklet specializes in the serious function CYP2D6 performs within the human liver. It examines the genetic, epigenetic, physiological, pathological, and structural components of the gene that govern the hugely variable metabolism of a couple of medications in medical use. It highlights the influence of the sensible roles of CYP2D6 on medical perform and drug improvement and likewise discusses implications for special medication, innovations to prevent antagonistic drug reactions, and paths for destiny research.

Cytochrome P450 2D6

is a special, priceless booklet concentrating on a unmarried yet immensely strong human gene. It presents the 1st unmarried resource of accomplished info on CYP2D6 that serves as an immense reference for scientific, biomedical, pharmaceutical, and nursing researchers, practitioners, and students.

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Cytochrome P450 2D6: Structure, Function, Regulation and Polymorphism

Cytochromes are proteins that catalyze electron move reactions of recognized metabolic pathways and are labeled in a number of superfamilies. The CYP, or P450, superfamily money owed for ninety% of the oxidative metabolism of medical medications. One member of this superfamily, P450 2D6 (or CYP2D6), singlehandedly metabolizes approximately 25% of all drugs within the human liver.

Extra info for Cytochrome P450 2D6: Structure, Function, Regulation and Polymorphism

Example text

1998; Sinz et al. 2008; Smutny et al. 2013; Tompkins and Wallace 2007; Waxman 1999; Zhu 2010). Induction of hepatic CYPs by drugs and other compounds can occur by increasing the intrinsic clearance, thereby increasing the extraction ratio, or by increasing the hepatic blood flow. , posttranslational stabilization) (Dickins 2004; Lin and Lu 1998, 2001; Tompkins and Wallace 2007; Waxman 1999). Unlike hepatic enzyme inhibition, induction takes time (hours or days) and is a function of chronic exposure.

It is thought that 1B1 can metabolize a key signaling molecule involved in eye development, possibly a steroid.

2005, 2006), CYP2B6 (Gay et al. 2010b; Shah et al. 2011, 2012; Wilderman et al. 2013), CYP2A13 (DeVore et al. 2012; DeVore and Scott 2012a; Smith et al. 2007), CYP2B6 (Gay et al. 2010b; Shah et al. 2011), CYP2C8 (Schoch et al. 2004, 2008), CYP2C9 (Williams et al. 2003), CYP2C19 (Thelen and Dressman 2009), CYP2D6 (Nguyen and Conley 2008; Rowland et al. 2006; A. Wang et al. 2012), CYP2E1 (Porubsky et al. 2008), CYP2R1 (Strushkevich et al. 2008), CYP3A4 (Williams et al. 2004; Yano et al. 2004), CYP7A1 (Tempel et al.

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