By Alain A. Vertès, Masayuki Inui, Hideaki Yukawa (auth.), Hideaki Yukawa, Masayuki Inui (eds.)
Corynebacterium glutamicum was chanced on in Japan in 1956 as a ordinary glutamate manufacturer. Its “microbial manufacturing unit” characteristics, akin to its physiological plasticity and strong catalytic functionalities, have for the reason that facilitated the advance of effective creation techniques for amino acids, nucleotides and supplementations.
This monograph illustrates how the data gleaned from entire genome sequencing permits the rational engineering of the whole mobile metabolism and the way platforms biology allows the additional optimization of C. glutamicum as a biocatalyst. facets of gene legislation, metabolic pathways, sugar uptake, protein secretion, phone department and biorefinery purposes spotlight the large biotechnological and biorefinery power.
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Additional resources for Corynebacterium glutamicum: Biology and Biotechnology
Glutamicum at productivities that are sufficiently high to enable the deployment of these bioconversions at the industrial scale. This is an important step forward as it paves the way to the development of a The Biotechnological Potential of Corynebacterium glutamicum 23 corynebacterial biorefinery to produce a range of industrial chemicals, in addition to amino acids. What is more, trends of increasing pricing have been observed for several polymers including PET, polypropylene, and polystyrene (Bohlmann 2007).
2011) represents an attractive means to improve the economics of corynebacterial processes, as is the possibility to use for bioremediation, compound detoxification, or isolation of valuable metals the biomass generated from these processes such as to produce L-lysine (Choi and Yun 2004; Mao et al. 2008; Das 2010). The large number of platform biochemicals that can now be produced using bacterial metabolism enables one to implement complex but economically optimized interconnected product lines (Fig.
2010). 4 Corynebacterium glutamicum in “Red” Biotechnology The use of C. glutamicum for producing pharmaceuticals has been limited to this date. Nevertheless, as discussed in a preceding paragraph and in chapter “Cell Division Mechanism of Corynebacterium glutamicum,” C. glutamicum constitutes an emerging technological platform for the production of pharmaceutical biologics such as proteins or recombinant antibodies. What is more, C. 2 g/l of the inhibitory transmitter g-aminobutyric acid (GABA) in 72 h (Zelder et al.