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By I. Chaikovsky, N. Sydorova

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Prediction of Coronary Heart Disease Risk in a South European Population: A Case-Control Study 37 6. Summary Coronary heart disease (CHD) is the most common cause of death in the industrialized countries. As these populations are aging, the prevalence of CHD is arising, and it is expected that this tendency will increase, in the future, due to the obesity epidemic that is rising all over the world and this will place a considerable burden on healthcare systems. The knowledge of new risk models, can improve the diagnosis capacity and prevention as well as the early treatment of this condition.

Progesterone increases hypoxic ventilatory response and reduces apneas in newborn rats. Respiratory Physiology & Neurobiology, 156, 9-16. ISSN 1569-9048 Madamanchi, N. , Vendrov, A. & Runge, M. S. (2005). Oxidative stress and vascular disease. Arteriosclerosis Thrombosis and Vascular Biology, 25, 29-38. ISSN 1079-5642 Mendelsohn, M. E. (2000). Nongenomic, estrogen receptor-mediated activation of endothelial nitric oxide synthase - how does it work? What does it mean? Circulation Research, 87, 956-960.

This is a topic that surely should be revisited once efforts toward gene discovery, identification of functional variants and pathways, and searches for less common variants allowing for heterogeneity have progressed (Ioannidis, 2009). 5. Conclusions The result of this study has demonstrated that a GRS, based on the presence of some susceptibility gene variants for coronary heart disease, allow the identification of subgroups with a significantly higher risk of coronary disease. The risk model that includes the GRS, the classical risk factors and some new risk markers, increases the GRS predictive power and provides a good estimation of the CHD risk.

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