Download Clinical Trials in Rheumatology by Ruediger Mueller, Johannes von Kempis PDF

By Ruediger Mueller, Johannes von Kempis

A large variety of healing stories has been released in rheumatology and scientific immunology. This quantity grows considerably via the 12 months. As such, it turns into more and more tough to maintain song of this multitude of reviews and the resultant healing developments. extra to this, a selected learn may be pointed out in a number of methods, both as a shortened model of the name or an acronym, including to the confusion. The e-book medical Trials in Rheumatology, moment version, presents an up-to-date precis of the real reports within the box for simple reference. each learn is proven with identify, acronym (if in existence), authors, entire quotation, research layout, and a quick evaluation of the trial's facts and major conclusions. An acronym finder is provided before everything of the e-book. This booklet is a helpful reference instrument for rheumatologists and different scientific specialties, in addition to for examine scientists attracted to immunomodulatory and chosen different drug cures in rheumatologic diseases.

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Extra resources for Clinical Trials in Rheumatology

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3 kg Death n=1 n=1 Osteoporosis n = 12 n = 15 28 Rheumatoid Arthritis: Atorvastatin TARA-Trial Trial of Atorvastatin in Rheumatoid Arthritis (TARA): double-blind, randomised placebo-controlled trial TARA: Trial of Atorvastatin in Rheumatoid Arthritis Substance Atorvastatin 40 mg/day (n = 58) Placebo (n = 58) Concomitant medication: DMARD therapy was continued Intra-articular injections with corticosteroids were permitted NSAIDs were permitted Oral corticosteroids were permitted Result Atorvastatin showed a modest but clinically apparent antiinflammatory effect Patients 116 patients with active rheumatoid arthritis • Despite DMARD therapy • ³ 6 swollen joints Plus 2 out of: • ³ 6 tender joints • Early-morning stiffness for ³ 30 min • Erythrocyte sedimentation rate ³ 28 mm/h Authors McCarey DW, McInnes IB, Madhok R, Hampson R, Scherbakov O, Ford I, Capell HA and Sattar N Publication Lancet.

The beneficial effect of methotrexate on radiologic progression compared with azathioprine was sustained after two years of follow-up Patients 64 patients with active rheumatoid arthritis • Failed to parenteral gold and D-penicillamine • ESR ³ 28 mm/h • Morning stiffness for ³ 45 min Authors Kerstens PJ, Boerbooms AM, Jeurissen ME, de Graaf R, Mulder J and van de Putte LB Publication J Rheumatol. 2000 May;27(5):1148–1155 Follow-up 4 years (continued) 34 Note Rheumatoid Arthritis: Azathioprine vs.

V. or orally) If discontinuation of gold or methotrexate: Initiation of other DMARD £ 6 weeks Complete remission ³ 6 months: Decrease of gold or methotrexate dose permitted NSAIDs permitted Osteoporosis prophylaxis permitted Fluorine, bisphosphonates and calcitonin not permitted Result Low-dose prednisolone given over two years in combination with background DMARD therapy substantially decreased radiographically detectable damage in patients with early disease Patients 192 patients with active early rheumatoid arthritis Authors Wassenberg S, Rau R and Zeidler H; Low-Dose Prednisolone Trail Group Publication Clin Exp Rheumatol.

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