By David Sutherland
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B. (2000) Human vascular and cardiac endothelia express mu opiate receptor transcripts. 185–191. W. (1996) Chronic diarrhea: an uncommon side effect of celiac plexus block. Anesthesia and Analgesia. Ol. 82:205-7. B. M. (1999) Molecular evolution of the opioid/orphanin gene family. 113, pp. 169-186. ; & Fong, Y. (2005) 5-fluorouracil and gemcitabine potentiate the efficacy of oncolytic herpes viral gene therapy in the treatment of pancreatic cancer. 1068-77. ; Laforet, J. & Kieffer, B. (1995) Identification of kappaand delta-opioid receptor transcripts in immune cells.
Thus, analgesia and restorative effects of HSV-Enk gene therapy will likely be effective in both somatic and visceral clinical pain. 5. Viral vectors: analgesic and anti-inflammatory potential Few studies to date report effective decreases in ongoing visceral pain with pharmacological treatments other than with opiates. , 1998), and opiates remain the primary therapeutic agent despite significant side effects and development of tolerance. Gene therapy is a novel drug delivery system capable of bringing over-expressed opiates directly to pancreatic tissues.
1992) δ- and κ-opioid receptor agonists inhibit plasma extravasation induced by bradykinin in the knee joint of the rat. 129–133. P. & Czymek, R. (2011) Evaluation of the quality of life after surgical treatment of chronic pancreatitis. 364-71. Hong, Y. V. (1995) Peripheral opioid modulation of pain and inflammation in the formalin test. 21–28. , Hargreaves, KkM (1990) Opiates suppress carrageenaninduced oedema and hyperthermia at doses that inhibit hyperalgesia. 95–103. B. J. (2005) Endoscopic ultrasound-guided fine-needle injection.