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Gastric Cancer UFT was studied in combination with radiation therapy in patients with locally advanced, inoperable gastric carcinoma. Tsukiyama et al. (66) evaluated combined modality therapy (CMT) consisting of UFT and mitomycin-C administered together with radiation therapy, and reported local control in 70% of patients with advanced inoperable gastric cancer. 5. Pancreatic Cancer Robert et al. 8 Gy/d). 5 mo (range 4–19 mo) and the median time to progression of 9 mo. Patient accrual was stopped because an MTD had not been reached at the 300 mg/m2/d dose of UFT.

5-FU-induced radiosensitization of HT29 human colon cells is potentiated by LV. HT29 cells were exposed for 14 h to: median alone (᭺), 10 umol/L LV (᭹), 1 umol/L 5-FU (᭿). Cells were assessed and data are expressed as described in Fig. 4. 3. BIOMODULATION The DNA-mediated effects of fluropyrimidines can be modulated by a number of agents, such as leucovorin (LV), levamisole, and interferon-alpha (IFN-alpha). LV prolongs TS inhibition by increasing the availability of the reduced folate cofactor necessary for formation of the inactive TS–FdUMP complex (21) (Fig.

Manipulation of cellular PKC levels through transfection and antisense oligonucleotide strategies have indicated a role in carcinogenesis and cellular differentiation. Preclinical studies, which have examined the activity of a reversible inhibitor (PKC412) of certain PKCs including cdk1/cyclin B1, have found that it has substantial antitumor activity in a variety of murine xenografts on its own (84). Furthermore, studies looking at the administration of this drug in combination with radiation have shown unique mechanisms for induced tumor growth delay depending on the p53 status of the tumors.

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