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By I. Leusen, J. Weyne (auth.), Professor Dr. Marianne E. Schläfke, Dr. Wolf R. See M.A., Professor Dr. Hans-Peter Koepchen (eds.)

This quantity comprises the papers provided on the symposion on important Neurone setting and the regulate platforms of respiring and circulate held at Bochum, October 5-7,1981 in honour of Prof. Dr. Dr. h.c. Hans H. Loeschcke, who retired in March 1981. His discovery of ventral medullary substrates forming a necessary force for the ventilatory in addition to for circulatory keep an eye on structures, and the elaboration of this idea over the past 25 years have profoundly prompted the strategies during this box. In an age of continuing specializa­ tion on partial mechanisms, his strategy has continuously emphasised the integrative facets of the regulate platforms, specifically the function of the respiration keep an eye on process for the ionic homeostasis of the mind and the shut interrelation among neuronal breathing and cardiovascular keep watch over. This common goal implies the combo of physico­ chemical and neurophysiological methods in addition to the research of peripheral functionality of respiratory and stream, themes that are frequently dealt with individually in response to different methods.

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Extra resources for Central Neurone Environment and the Control Systems of Breathing and Circulation

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1980). For these reasons, the influence of carbonic anhydrase on the time constant of the pH change in treated samples may be excluded. The most important observation from the in vitro studies is that the pattern of the pH response in SITS treated brain slices approached that in mock CSF. The question arises whether or not the diminution of the time constant of the pH change is an indicator of the inhibition of the HC0"3 -cr exchange mechanism. In case of a complete block of the HC0"3 -cr exchange by stilbene derivatives, both intra- and extracellular compartments would be equilibrated separately in respiratory acidosis.

200 tlmull a Fig. 2 5 I 10 15 I 20 Fig. 1. Time courses of the changes of intracellular [Na+]i' plasma -[K+]p' -[Cr]p' -[HC03-lp. nomycin to whole human blood • Fig. 2. xchange of sodium against potassium whereas the bicarbonate- and chloride concentrations remain nearly uninfluenced. especially in the beginning of the experiment. The blood cell volume is constant. Human erythrocytes with the same valinomycin concentration but additionally treated with ouabain in order to block the active sodium-potassium transport showed a slow outflux of chloride and potassium.

Mathematical Analysis of the lonal and Gaseous Exchange in the Brain Theory: For the purpose of mathematical description the brain tissue is thought to consist of at least three compartments: a) the intracellular fluid (ICF), represented mainly by the glial cells, in which C02 is produced, hydrated and dissociated into bicarbonate and H+-ions. This reaction is catalyzed. b) the extracellular fluid (ECF), an in vitro unbuffered fluid which doesn't contain protein. c) the plasma compartment. K. Miickenhoff et al.

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