Download Cardiac Energetics: From Emax to Pressure-Volume Area by Martin M. LeWinter, Hiroyuki Suga, Matthew W. Watkins PDF

By Martin M. LeWinter, Hiroyuki Suga, Matthew W. Watkins

Most of the development in cardiac energetics in recent times has been spurred through the pressure-volume quarter thought, the typical extension into energetics of prior pioneering paintings delineating the time-varying elastance framework for ventricular contraction. The booklet attracts jointly a extensive spectrum of researchers - simple, utilized and scientific - having a shared curiosity within the energetics of cardiac muscle and ventricle, offering an outline of the present country of the art.

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Stennett, Donna Zwas, Kazuhide Ogino and James P. Morgan INTRODUCTION The course of research in cardiovascular physiology has been influenced greatly by the time-varying elastance [E(t)] theory of ventricular contraction which was introduced in the early 1970's (1). In principle, the E(t) function describes the time variations in instantaneous ventricular volwne-elastance during a beat and was proposed as a load-independent characterization of dynamic ventricular pwnp properties. Additionally, the value of E(t) at end systole (E es), which is the slope of the end-systolic pressure-volwne relationship (ESPVR).

O ~ .. -.. S Q. 6 o 1-. « ~ • • '0-:-:::' III Q. ~ ~ ::t. 4 6 control rabbit • .. hyperthyroid rabbit + N co U /. 2 • cardiomyopathic hamster o 20 40 60 80 tOO myosin a-heavy chain isozyme (%) Fig. 3. Relationship between Ca++ -activated ATPase activity and myosin isoform composition. 22 range of %ex -MHC for hamster myosin was limited, we cannot be sure whether the relation between %ex -MHC and velocity falls on the same relation for rabbit myosin; 2) Although there was a strong positive correlation, the relation is not necessarily linear.

2. Left: LV ESPVRs measured from isolated canine heart under ejecting and isovolumic conditions. Right: model ventricle behaves same way in response to the load change. o Isovolumic Ejecting 0 0 ° .......... 15 0 .... :0 .... , (/) ...... ) E r--.. 30 ::J .......... 05 /" a - Arbitrary intercept 1000 2000 3000 PVA (mmHg·ml) Fig. 3. Left: mV02-PVA relationship from isolated heart under isovolumic and ejecting conditions. Right: energetics of model LV responds the same way to the change in load.

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