Download Brain Energetics and Neuronal Activity: Applications to fMRI by Robert G. Shulman, Douglas L. Rothman PDF

By Robert G. Shulman, Douglas L. Rothman

Книга mind Energetics and Neuronal task: functions to fMRI and drugs mind Energetics and Neuronal task: functions to fMRI and MedicineКниги Медицина Автор: RobertÿG. Shulman, Douglas L. Rothman Год издания: 2004 Формат: pdf Издат.:Wiley Страниц: 336 Размер: 4,8 ISBN: 0470847204 Язык: Английский0 (голосов: zero) Оценка:This publication is exclusive in linking in vivo 13C NMR measurements of neuronal job and energetics with purposes to practical imaging and sure illness states It offers a basic neurochemical clarification of mind job appropriate to sensible imaging, theories of neuronal task and affliction states, e.g. epilepsy, psychiatric illnesses and developmental problems. Novel and in all likelihood arguable Will encourage destiny study instructions

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LOCALIZATION OF FUNCTIONALLY ACTIVATED ENERGY METABOLISM AT THE TISSUE LEVEL Traditional electrophysiology focuses largely on electrical recordings from neurons, and it was, therefore, originally assumed that the increases in local CMRglc associated with functional activation observed with the [14 C]DG method were primarily in perikarya. 5. [14 C]Deoxyglucose autoradiograph of normal, conscious rat brain. Greater optical density reflects greater CMRglc . Note high rate in molecular layer of hippocampus.

It is assumed that the reader is familiar with the basic concepts of (organic) NMR spectroscopy. 2. 1. 9 %). Since nearly all metabolites contain protons, in vivo 1 H MRS is, in principle, a powerful technique to observe, identify and quantify a large number of biologically important metabolites in intact tissue. However, the application of 1 H MRS to intact tissues in vivo is challenging for a number of reasons. Firstly, the water resonance is several orders of magnitude larger than the low-concentration metabolites, making metabolite detection difficult and ambiguous.

Orkand, R. , Nicholls, J. , and Kuffler, S. W. 1966. Effect of nerve impulses on the membrane potential of glial cells in the central nervous system of amphibia. J. Neurophysiol. 29: 788–806. Owen, O. , Moran, A. , Kemp, H. , Sullivan, J. , Herrera, M. , and Cahill, G. F. 1967. Brain metabolism during fasting. J. Clin. Invest. 46: 1589–1595. , and Magistretti, P. J. 1994. Glutamate uptake into astrocytes stimulates aerobic glycolysis: A mechanism coupling neuronal activity to glucose utilization.

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