By Kursad Turksen
This finished quantity explores capabilities, pathologies, and purposes of stem cells relating to the niches within which they increase. Ten chapters conceal the topic extensive, from a ancient viewpoint via signaling, hormonal keep watch over, quiescence, biomimetics, epigenetics, engineering innovations for emulating, tumorigenesis and extra. The bankruptcy authors symbolize a large diversity of foreign services and perspectives.
This installment of the preferred Stem phone Biology and Regenerative drugs sequence offers authoritative, overseas views in this speedily transforming into box. Biology of Stem mobile Niche is a perfect complementary quantity to Tissue-Specific Stem mobile area of interest and grownup Stem Cells, moment variation and may be necessary to clinicians and researchers operating with stem cells in addition to to postgraduate trainees who're learning them.
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Kiel MJ, Yilmaz OH, Iwashita T, Yilmaz OH, Terhorst C, Morrison SJ. SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells. Cell. 2005;121(7):1109–21. 43. Kobayashi MSE. Regulation of murine hematopoietic stem cell quiescence by Dmtf1. Blood. 2011;118:6562–71. 44. Kunisaki Y, Bruns I, Scheiermann C, Ahmed J, Pinho S, Zhang D, et al. Arteriolar niches maintain haematopoietic stem cell quiescence. Nature. 2013;502(7473):637–43. 45. Leon-Rico D, Aldea M, Sanchez R, Segovia JC, Weiss LA, Hidalgo A, et al.
Altogether, these experiments emphasize the effects of microenvironment on the programming of epithelial cells into speciﬁc lineages. Since cell fate may be regulated by speciﬁc signals arising from the basement membrane, including growth factors and cytokines, it is possible that in the cornea, the decision to leave the stem cell compartment could be dependent on ECM composition and structure at the limbus. Under such circumstances, corneal epithelial stem cells could follow one of two alternative, different courses.
Chitteti BRCY, Poteat B, Rodriguez-Rodriguez S, Goebel WS, Carlesso N, Kacena MA, Srour EF. Impact of interactions of cellular components of the bone marrow microenvironment on hematopoietic stem and progenitor cell function. Blood. 2010;115(16):3239–48. 20. Chitteti BR, Cheng YV, Streicher DA, Rodriguez-Rodriguez S, Carlesso N, Srour EF, Kacena MA. Osteoblast lineage cells expressing high levels of Runx2 enhance hematopoietic progenitor cell proliferation and function. J Cell Biochem. 2010;111(2):284–294.