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Extra resources for Biochemical Pharmacology. Lecture Notes
B: Electroneutralitywill oppose entropy. c: The Nernst equation describes the membrane potential that ensues when entropy and electroneutrality are in equilibrium. membrane potential is not identical to either of these values (which it would if the membrane were selectively permeable to either K+ or Na+ only). Clearly, what we need is a means to determine the membrane potential if we have multiple permeable ion species. 3 in its special case for K+ and Na+). When comparing it with the Nernst equation, you see that the Goldman equation introduces one additional parameter P (for permeability), which has a specific value for each ion present.
2. 5b) targets it to the α-adrenoceptor, the chemical reactivity of the ethyleneimino group is rather non-selective and will cause molecules not bound to the receptor to react in random locations,potentially causing harm including genetic damage. Accordingly, phenoxybenzamine is not the drug of first choice in most clinical indications of α-adrenoceptor blockade. 8 µM Phenoxybenzamine is the drug of choice in one particular disease called phaeochromocytoma. This is a tumour of the adrenal glands that produces and intermittently releases very large amounts of epinephrine and norepinephrine, causing dangerous spikes in blood pressure.
It does not imply oligomeric structure of the receptor or cooperativity of binding. 11. Activation 5-hydroxytryptamine (=serotonin) receptors by various agonists. a: Principle of the assay. Cell membranes carrying the receptors and associated G-proteins were incubated with the agonists and with 35S-GTP. The radioactive label will bind to the G protein when the receptor is activated by an agonist. b: Dose-response curves for receptor activation by 35SGTP binding in response to various agonists. mation.