By U. Fano
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Extra resources for Atomic collisions and spectra
1996; ASPEGREN et al. 1998), such a factor could act on viral mRNAs arriving or already present in these defined compartments. Recently, a cellular protein called EIB-AP5 was identified that binds to Ad5 EIB-55kDa in vitro and in virus-infected cells (GABLER et al. 1998). :;;di:'~-;;~:::'~i 100 200 p53 E40rf6 E1B·AP5 300 400 496 • • • • Fig. 3. Domains and motifs in the Ad5 EI B-55kDa protein. The amino acid sequence of the leucine·rich NES (residues 83-93) is indicated above. RNP denotes the region implicated in non-specific RNA-binding (HORRIDGE and LEPPARD 1998).
1996), are Nuclear Export of Adenovirus RNA 43 selectively exported by an E IB-55kDa-dependent mechanism (see Sect. 5). Clearly further work is needed to test the validity of such a model. 7 Requirement for EIB-55kDa and E40rf6 in Late Viral RNA Export Is Dependent on the Type of Host Cell As described (Sect. 2), early analyses of the Ad2/Ad5 replicative cycle were performed primarily in HeLa cells, where viral replication is strictly dependent on E IB-55kDa and E40rf6 functions (for references, see Sect.
I Virol 73:3246-3257 Zhi Y, Sciabica C, Sandri-Goldin RM (1999) Self interaction of the herpes simplex virus type I regulatory protein (CP27. Virology 257:341-351 Nuclear Export of Adenovirus RNA T. DOBNER and J. KZHYSHKOWSKA Introduction. 25 2 Adenovirus [nfectious Cycle. 7 Nuclear Export of Adenovirus RNA. RNA Export: General Considerations. Evidence for Regulated RNA Export in Adenovirus-Infected Cells. Regulated Viral RNA Export Is Linked to Alterations in Nuclear Organization E40rf3 and E40rf6 Maintain the Stability of Major Late RNAs in the Nucleus.