By Angela F. Drew
In Atherosclerosis: Experimental tools and Protocols, Angela Drew and a panel of specialists have assembled a accomplished number of conventional and state of the art options for investigating this disorder and its attainable remedies. each one without problems reproducible strategy contains step by step directions and useful information about pattern assortment, the alternative of animal version approach, experimental layout, and sensible information research innovations. complete and richly certain, Atherosclerosis: Experimental equipment and Protocols allows all biomedical investigators to choose these optimized options that could be so much fruitfully used to review the improvement, development, and remedy of atherosclerotic lesions this day.
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Additional info for Atherosclerosis: Experimental Methods and Protocols (Methods in Molecular Medicine)
F. 210 The mean % composition of the major classes of lipoproteins is given: PL, phospholipid; chol, cholesterol and cholesterol ester; TAG, triglyceride. The mobility from the origin is pre-β; β; α see Fig. 1 for example. The density is the band at which the lipoproteins float from salt gradients. This chapter describes the use of self-generating continuous gradients of iodixanol for the separation of plasma lipoproteins (6). This method has unique advantages over the current reference method.
Newland, D. , Young, S. , Hammer, R. , Sanan, D. , and Hobbs, H. H. (1995) Relative contributions of apolipoprotein(a) and apolipoprotein-B to the development of fatty lesions in the proximal aorta of mice. Arterioscler. Thromb. Vasc. Biol. 15, 1911–1916. 22. , and Charo, I. F. (1998) Decreased lesion formation in CCR2-/- mice reveals a role for chemokines in the initiation of atherosclerosis. Nature 394, 894–897. 23. Plump, A. , Scott, C. , and Breslow, J. L. (1994) Human apolipoprotein A-1 gene expression increases high density lipoprotein and suppresses atherosclerosis in the apolipoprotein E-deficient mouse.
Centrifugation is the ‘gold-standard’ for the analysis of plasma lipoprotein classes and beta quantitation, and other analytical procedures (1–4). Lipoprotein classes are separated by flotation of plasma or serum in a series of centrifugation steps in which the density of the plasma is increased sequentially by addition of potassium bromide. Alternatively, plasma is layered beneath a discontinuous gradient and centrifuged to separate the lipoprotein classes in a single step. However, it is impractical to use these methods in a routine analytical or clinical laboratory because of the long centrifugation steps required.