By Edward F. Plow PHD, Peter Kelly MD (auth.), Arman T. Askari, A. Michael Lincoff (eds.)
Substantial morbidity and mortality continues to be linked to thrombotic occasions has inspired the quick growth of the to be had armamentarium to strive against pathologic thrombosis. Pathologic thrombosis performs a vital position within the pathogenesis of acute coronary syndromes (ACS), ischemic issues of percutaneous coronary intervention (PCI), venous thromboembolic disorder, and embolic problems of arrhythmias and diverse cardiomyopathies. Written through specialists within the box, Antithrombotic Drug remedy in Cardiovascular Disease conscientiously examines person and numerous mixtures of the on hand antithrombotic regimens together with fibrinolytic brokers, antiplatelet remedies (aspirin, thieneopyridines, glycoprotein IIb/IIIa inhibitors), and anticogulant cures (unfractionated heparin, low-molecular-weight heparins, direct thrombin inhibitors, and artificial issue X inhibitors), non-ST-segment elevation (NSTE) ACS and ST-segment elevation myocardial infarction (STEMI). a close assessment, Antithrombotic Drug remedy in Cardiovascular Disease provides the proof demonstrating the efficacy of accessible antithrombotic cures in particular affliction states akin to atrial traumatic inflammation, cardiomyopathy, valvular middle disorder, and heparin-induced thrombocytopenia (HIT).
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Extra resources for Antithrombotic Drug Therapy in Cardiovascular Disease
The Extrinsic Pathway The so-called Extrinsic Pathway of coagulation, comprising tissue factor and factor VII, is activated by tissue injury or cellular activation and is likely the primary mechanism for in vivo hemostasis (2,34). 4). Tissue factor is an intrinsic membrane glycoprotein expressed on many vascular wall cells, such as smooth muscle cells, pericytes, and fibroblasts (34,36). Constitutively expressed cell-based tissue factor can be exposed to the blood following vascular injury, but tissue factor expression can also be induced on vascular endothelial cells and leukocytes by thrombin and inflammatory stimuli (34,37,38).
J Thromb Haemost 4:295–306 120.
Some disorders, such as the antiphospholipid antibody syndrome (APS) and heparin-induced thrombocytopenia (HIT), have clear clinical associations with both arterial and venous thrombosis (17). The thrombosis in HIT, for example, is thought to be multifactorial, with platelet activation, endothelial activation, and thrombin generation all contributing to the pathophysiology (18). In the following sections, the physiology of coagulation and its regulation will be described, followed by a discussion of coagulationassociated risk factors for both arterial and venous thrombosis.