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By David R. Gross D.V.M., Ph.D. (auth.)

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The cammon carotid arteries were ligated am cut, vagus am depressor nerves cut bilaterally in the neck w ...... 1-10 g/ml up to 2,000 g/ml Isolated muscle Isolated right ventricular papillary muscle Isolated, dissected pieces of pial arteries, approximately 5 mm long papillary 10-5M to 10-4M concentrations in both perfusion , various concentrations a developed No change in maximum tension or dT/dt at low dose but both at higher dose isometric decreased Dose dependent dilation, effect blocked by naloxone.

14 Rabbits 33 34 2 Only high (9 mg/kg) dose resulted in significant changes. Heart rate and aortic pressures, systolic, diastolic and mean, all decreased, peak effect after 1 hour. Inhibi ted noradrenalin induced increase in blood pressure and reflex bradycardia, partially antagonized isoprenaline~induced decrease in blood pressure with no effect on tachycardia, norepinephrine release was enhanced. 16 Guinea Pigs Cheek-pouch preparation, anesthesia not described. , sham treated control group ? 15 Hansters injection.

14 Rabbits 33 34 2 Only high (9 mg/kg) dose resulted in significant changes. Heart rate and aortic pressures, systolic, diastolic and mean, all decreased, peak effect after 1 hour. Inhibi ted noradrenalin induced increase in blood pressure and reflex bradycardia, partially antagonized isoprenaline~induced decrease in blood pressure with no effect on tachycardia, norepinephrine release was enhanced. 16 Guinea Pigs Cheek-pouch preparation, anesthesia not described. , sham treated control group ? 15 Hansters injection.

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