Download An Antigen Depository of the Immune System: Follicular by A. K. Szakal, Z. F. Kapasi, S. T. Haley (auth.), Marie H. PDF

By A. K. Szakal, Z. F. Kapasi, S. T. Haley (auth.), Marie H. Kosco-Vilbois (eds.)

Follicular dendritic cells (FOe) are targeted between cells of the immune procedure. whereas their morphological features re­ sulted of their inclusion as a 'dendritic mobilephone type', tt1ey fluctuate fairly considerably from the opposite participants of the dendritic mobile family members. not like T-cell-associated dendritic cells or the Langerhans cells present in the outside, FOe dwell in hugely equipped B mobile follicles inside secondary lymphoid tissues. This web site of resi­ dence supplied a nomenclature committee in 1982 with the second one descriptive issue for the derivation in their identify. The cardinal function of FOe is to catch and preserve antigen at the floor in their dendritic approaches for prolonged quantities of time and it's this selection that offers the conceptual compo­ nent for the identify of this e-book. based on an antigenic problem, fundamental B mobilephone follicles suffer dynamic occasions, giving upward thrust to germinal facilities that are linked to activation, enlargement, and differentiation methods of B cells. The interactions of B cells with Foe and T cells within the germinal facilities are crucial for producing the total repertoire of antibody isotypes acquired in the course of an antibody reaction. moreover, stimuli both initiated or major­ tained in the course of the germinal middle reponse ends up in creation of excessive affinity antibodies throughout the strategies of somatic muta­ tion and clonal choice. during this context, FOe act as a pivotal resource of antigen. They collect overseas proteins (e. g.

Show description

Read Online or Download An Antigen Depository of the Immune System: Follicular Dendritic Cells PDF

Best nonfiction_8 books

Multimedia Tools and Applications

Multimedia computing has emerged within the previous couple of years as an important region of study. Multimedia desktops have opened quite a lot of functions by way of combining a number of info resources, equivalent to voice, photos, animation, photographs, audio, and full-motion video. taking a look at the large photo, multimedia might be seen because the merging of 3 industries: the pc, communications, and broadcasting industries.

Acoustical Holography: Volume 2

This quantity provides the complaints of the second one overseas Sym­ posium on Acoustical Holography, which used to be held on the Douglas complicated examine Laboratories on 6 and seven March 1969, fifteen months after the 1st symposium. house used to be constrained to approximately a hundred and ten seats, with representatives from 9 international locations attending.

Die chemische Entwicklungserregung des tierischen Eies: Kunstliche Parthenogenese

This can be a pre-1923 old replica that was once curated for caliber. caliber coverage used to be performed on each one of those books in an try to get rid of books with imperfections brought via the digitization approach. even though now we have made top efforts - the books could have occasional error that don't abate the studying adventure.

Life Under Extreme Conditions: Biochemical Adaptation

Of their first actual lecture biochemists study that biomolecules, particularly nucleic acids, proteins and lipids, are super temperature delicate and should denature and lose their functionality simply. Then how do Archaebacteria live on in scorching springs or Antarctic fishes which stay in ice-cold water? the way in which nature engineered subcellular constructions, lipid membranes or proteins to fulfill the biochemical specifications of maximum stipulations - like hot temperature or salt concentrations - is defined in existence below severe stipulations.

Additional resources for An Antigen Depository of the Immune System: Follicular Dendritic Cells

Sample text

Ig hypermutation starts after a 6-day latency period (JACOB et al. 1993). There may be a link between immune complex retention of FOC, mutation, and affinity selection. No direct action of FOC on Ig hypermutation in B cells has been demonstrated, but such action is imaginable, since mutations appear to be restricted to the germinal centers (BEREK et al. 1991; KEPLER and PER ELSON 1993) and the mutation process starts at about the same time as immune complex retention by FOC. The proposition that B cell activation in the T-dependent zone gives the starting signal for hypermutation is hardly tenable, since the mutations occur mainly after day 6.

1990), one might suspect reciprocal influences between the two cell types. COSGROVE et al. (1991) discovered a CD4+ T cell type in the lymph follicles of mice lacking MHC class II molecules, whereas the other peripheral lymphoid tissues were devoid of CD4+ cells. These quite specific cells are relatively large in size, T cell receptor a[3+, and express high levels of CD44. Germinal center T cells represent 5%-20% of the lymphoid cell popUlation; most are CD4+ cells and CD8+ cells are rare (RITCHIE et al.

Adv Exp Med Bioi 237:209-214 Gray D, Skarvall H (1988) B-cell memory is short-lived in the absence of antigen. Nature 336: 68-69 Gray D, MacLennan ICM, Lane PJL (1986) Virgin B cell recruitment and the lifes span of memory clones during antibody responses to 2,4-dinitrophenyl-hemocyanin. Eur J Immunol16: 641-648 Gray D, Kosco M, Stockinger B (1991) Novel pathways of antigen presentation for the maintainance of memory. Int Immunol3: 141-148 Groscurth P (1980a) Non-lymphoid cells in the lymph node cortex.

Download PDF sample

Rated 4.30 of 5 – based on 34 votes