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4. Conclusions In the last few years, our knowledge about of the human genome improved considerable. Still we are very far from the total understanding of the genomic background of complex diseases, but the news high-throughput technologies together with other complementary tools, as bioinfomatic, have contributed to highly increase our understanding of these complex disorders, and most importantly, have produced a change in the focusing of biological studies. The concept of biological systems open a broader, integrated view of biological system will yield a more complete understanding of disease, providing improved tools for identifying prognostic, diagnostic, biomarkers and treatment.

J Biomed Biotechnol, IISN 1110-7243. Sleiman, PM. & Hakonarson, H. (2010). Recent advances in the genetics and genomics of asthma and related traits. 307-312, IISN 1040-8703. Southern, EM. (1975). Detection of specific sequences among DNA fragments separated by gel electrophoresis. 3, (November 1975), pp. 503-517, ISSN 0022-2836. ; Tölgyesy, G. & Falus, a (2008). British Journal of Pharmacology , Vol. 153, No. 8 (Apr 2008), pp. ; Mukhopadhyay, S. & Palmer, CN. (2008). A polymorphism controlling ORMDL3 expression is associated with asthma that is poorly controlled by current medications.

Hourihane, J & Sampson, HA. (2003). Measurement of peptide-specific IgE as an additional tool in identifying patients with clinical reactivity to peanuts. 202-207, IISN 0091-6749. ; Palmer, CN. (2009). Chromosome 17q21 gene variants are associated with asthma and exacerbations but not atopy in early childhood. 179-185, IISN 1073-449X. Bloom, G. ; Yang, IV ; Boulware, D. ; Quackenbush, J. (2004). Multi-platform, multi-site, microarraybased human tumor classification. Am J Pathol , Vol. 164, No.

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