By Nancy E. Lane (auth.), Nancy E. Lane (eds.)
In Aids hypersensitivity and Rheumatology, scientific specialists survey the newest info on hand at the key rheumatic and allergic concerns that physicians face in treating the HIV-infected sufferer. Their articles specialise in the rheumatologic and dermatologic manifestations of HIV-1 an infection, which come with arthritis, myopathies, vasculitis, sicca syndrome, different autoimmune phenomena, and psoriasis. additionally they learn the query of allergies in HIV sufferers, together with drug allergy, with specified recognition given to antagonistic reactions to trimethoprim-sulfamethoxazole, the main usually prescribed anti-infective. sensible recommendation for the analysis and remedy of those difficulties is given in complete.
Aids hypersensitive reaction and Rheumatology bargains physicians a finished consultant to the prognosis and therapy of the allergic, immunologic, and rheumatic problems in HIV sufferers. Authoritative and practice-oriented, the e-book is destined to develop into a customary source for all these treating AIDS sufferers today.
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One possible pathogenetic explanation is the direct infection of muscle cells by HIV. In vitro studies seem to support this hypothesis. In contrast, in vivo experiments using monkeys infected with simian retrovirus type I (a retrovirus closely related to HIV that produces polymyositis in monkeys) have shown that HIV can be found in inflammatory cells surrounding or invading muscle fibers, but not directly in the muscle fibers themselves (57). Furthermore, with the exception of one report of the presence of HIV-p24 antigen in the cytoplasm of degenerating muscle fibers (53), most investigators have not detected viral antigens or particles by immunocytochemical analysis or by electronmicroscopy in muscle fibers, nor have they successfully cultured HIV from affected muscle tissue in patients with HIV-associated polymyositis (53,55,58,59).
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