By Saul L. Neidleman
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Extra info for Advances in Applied Microbiology, Vol. 44
The producing culture was isolated hom a Chinese soil sample. 38 nM, respectively. Bassiatin did not inhibit ACAT at concentrations up to 10 yM. Cell adhesion and cell adhesion molecules have been implicated in various diseases, and this has created an interest in antiadhesion compounds. Hayashi et al. (1995) have isolated antiadhesant compounds from a Microsphaeropsis culture obtained from a soil sample. The two 56 CEDRIC PEARCE OH (163) Bassiatin OH I OH I 0 0 HO H3C 0U C H s (164) MacrospheliieA (165) MacrosphelideB 0 H (166) Eporactaene STRUCTURES 162-1 6 6.
Originally isolated from a soil sample. When this fungus was cultured in a stationary potato dextrose broth, fusarielin A-D (109-112) were produced. Biosynthetic studies using I3C-labeled precursors demonstrated that these compounds are derived via a decaketide that undergoes five methionine-derived methylation reactions. Significantly, these results show that, while fusarielin contains the decalin motif, albeit somewhat disguised, it is not derived from a decalin precursor since the labeling pattern reported would be different if it were.
1995a). , 1995). Favolon was produced in a medium containing yeast extract, malt extract, and glucose, and was present in the mycelia. Favolon displayed potent antifungal activity when tested against ascomycetes, basidiomycetes, oomycetes, and zygomycetes. The sterol was not active against bacteria, neither was it active against L1210 cells. This research group also isolated a new strobilurin, hydroxystrobilurin A (117),which was reported from basidiomycetes Pterula spp. , 1995). A mycelial culture obtained from the fruiting body of a fungus collected from a German forest was grown in a medium containing yeast extract, malt extract, and glucose in an aerated fermen- m) 38 CEDRIC PEARCE OCH3 (115) STRUCTURES 113-115.